Atrial Fibrillation Clinical Trial Update

There are numerous ongoing clinical trials on atrial fibrillation (AF) currently taking place. Included is a brief listing of updated AF trials for 2008.

An Observational Study to Assess the Efficacy of Continuous Sub-cutaneous Arrhythmia Monitoring Versus Conventional Ambulatory ECG Monitoring in Detecting Atrial Fibrillation in Patients After Pulmonary Vein Isolation

Number of Patients: 50 Trial Start Date: June 2008 Estimated Completion Date: January 2011 Status: Recruiting Purpose: The primary aim of this diagnostic, open label study is to assess the efficacy of continuous rhythm monitoring with an implantable loop recorder (ILR) compared to conventional ambulatory electrocardiography in detecting episodes of AF after pulmonary vein isolation (PVI). The secondary purpose is to assess the efficacy of PVI during a two-year follow-up and to assess the reliability of the ILR in detecting AF. Contact: Axel Brandes, MD, +4565411896 ext. 3646, axel.brandes @ouh.regionsyddanmark.dk

EPLERAF Study: Eplerenone in the Prevention of Atrial Fibrillation Recurrences After Cardioversion

Number of Patients: 220 Trial Start Date: March 2008 Estimated Completion Date: March 2011 Status: Recruiting Purpose: The purpose of this randomized, double-blind study is to determine whether Eplerenone reduces AF recurrences within the first eight weeks after electrical cardioversion of persistent AF. Contact: Principal Investigator Michael Böhm, MD, Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, +49-6841-1623372, boehm@uks.eu

Clinical and Economic Conse-quences of Left Atrial Bipolar Radio-frequency Ablation of Persistent and Permanent Atrial Fibrillation During Cardiac Surgery: A Prospec-tive, Randomized, Multicenter Trial

Number of Patients: 100 Trial Start Date: September 2005 Estimated Completion Date: N/A Status: Recruiting Purpose: The purpose of this trial is to study the clinical effects of intra-operative radiofrequency (RF) ablation in patients with persistent or permanent AF and the indication for an implantation of a heart valve prosthesis or coronary bypass surgery. This randomized, open label study will examine if and to what extent the quality of life and the use of medical care differs between patients with and without ablation. Contact: Principal Investigator Calin Vicol, Professor, Klinikum der Universität München Großhadern Cardiac Surgery, +089 7095 2358, calin.vicol@med.uni-muenchen.de

Randomized Study Comparing Cardioversion vs. Catheter Ablation in Patients With Persistent Atrial Fibrillation

Number of Patients: 130 Trial Start Date: August 2005 Estimated Completion Date: December 2008 Status: Recruiting Completed Purpose: The aim of this randomized study is to evaluate the efficacy of two different approaches for conversion of persistent atrial fibrillation: non-invasive (external electrical cardioversion) and invasive (catheter ablation. Contact: Principal Investigator Heidi L. Estner, MD, Deutsches Herzzentrum Muenchen, +0049 89 1218 2020, estner@dhm.mhn.de

Atrial Fibrillation Mechanism Analysis Through Ibutilide Adminis-tration During Pulmonary Vein Ablation

Number of Patients: 50 Trial Start Date: October 2007 Estimated Completion Date: December 2009 Status: Recruiting Purpose: To test the hypothesis that localized functional reentry maintains AF in humans, ibutilide will be administered intravenously in patients undergoing an AF ablation. The hypothesis of this study is that ibutilide will decrease the high frequency signals observed in AF suggesting the presence of micro reentrant circuits as the basic mechanism of AF, especially for the paroxysmal AF group. The potential difference in response to the ibutilide in patients with paroxysmal versus persistent AF may show the difference in the underlying mechanism of AF between these two groups. Contact: Principal Investigator Antonio Navarrete, MD, Staff Physician, Ball Memorial Hospital, 765-281-2000, annavarr@mac.com

Efficacy of Different Ablation Strategies in Achieving Long-Term Arrhythmia Control in Patients With Persistent or Permanent Atrial Fibrillation

Number of Patients: 147 Trial Start Date: October 2006 Estimated Completion Date: November 2009 Status: Recruiting Purpose: This study involves treatment for atrial fibrillation. Study participants will receive RF ablation. The purpose of this study is to compare the effectiveness of three different common ablation strategies in patients with persistent or permanent AF. Subjects will be randomized to be treated with one of the three strategies to see if there is a difference in how well atrial fibrillation is controlled after treatment. Contact: Principal Investigator Sanjay Dixit, MD, University of Pennsylvania. Tony Killian, RN, CCRC, 215-615-4772, killiana@uphs.upenn.edu For more information, please visit: www.clinicaltrials.gov